Wednesday Round Up #53

Excerpt from Jack Gilbert’s Poem “Moreover”

What we are given is taken away,
but we manage to keep it secretly.
We lose everything, but make harvest
of the consequence it was to us. Memory
builds this kingdom from the fragments
and approximation. We are gleaners who fill
the barn for the winter that comes on.

America Has a Drinking Problem

Still, cohesion would have been essential, and this is the core of Slingerland’s argument: Bonding is necessary to human society, and alcohol has been an essential means of our bonding. Compare us with our competitive, fractious chimpanzee cousins. Placing hundreds of unrelated chimps in close quarters for several hours would result in “blood and dismembered body parts,” Slingerland notes—not a party with dancing, and definitely not collaborative stone-lugging.

Human civilization requires “individual and collective creativity, intensive cooperation, a tolerance for strangers and crowds, and a degree of openness and trust that is entirely unmatched among our closest primate relatives.” It requires us not only to put up with one another, but to become allies and friends.

As to how alcohol assists with that process, Slingerland focuses mostly on its suppression of prefrontal-cortex activity, and how resulting disinhibition may allow us to reach a more playful, trusting, childlike state…

Sayette, for his part, has spent much of the past 20 years trying to get to the bottom of a related question: why social drinking can be so rewarding. In a 2012 study, he and Creswell divided 720 strangers into groups, then served some groups vodka cocktails and other groups nonalcoholic cocktails. Compared with people who were served nonalcoholic drinks, the drinkers appeared significantly happier, according to a range of objective measures. Maybe more important, they vibed with one another in distinctive ways. They experienced what Sayette calls “golden moments,” smiling genuinely and simultaneously at one another. Their conversations flowed more easily, and their happiness appeared infectious. Alcohol, in other words, helped them enjoy one another more.

Uri Hasson (Princeton) 2: Storytelling and Memories: How the Act of Storytelling Shapes our Minds

Uri Hasson explores how brain activity is shared between listeners of the same story, and how those shared neural responses are coupled to and shaped by the neural activity in the storyteller’s brain.

How does your brain change with each story that you hear? How can storytelling shape your memories? In this talk, Dr. Uri Hasson explores how brain activity is shared between listeners of the same story, and how those shared neural responses are coupled to and shaped by the neural activity in the storyteller’s brain.

The Brain-Changing Magic of New Experiences

After previous studies with animal subjects found that new experiences are beneficial for brain development, a group of researchers attempted a similar experiment in humans. They enlisted subjects in New York City and Miami and tracked GPS data on their phones, while texting them every other day to ask about their mood. The study was conducted pre-pandemic and published in Nature Neuroscience in May 2020.

“What we found was that for every person, on days when they displayed greater exploration, greater “roaming entropy”, they reported feeling happier. It’s as simple as that,” said co-author Dr. Aaron Heller of the University of Miami. His team then did a more nuanced analysis in which they collected how many new places their subjects visited. “The experience of novelty, or going to places you had never been before, actually seemed to have an even larger association with positive emotion on that day.”

Long-term gene–culture coevolution and the human evolutionary transition

It has been suggested that the human species may be undergoing an evolutionary transition in individuality (ETI). But there is disagreement about how to apply the ETI framework to our species, and whether culture is implicated as either cause or consequence. Long-term gene–culture coevolution (GCC) is also poorly understood. Some have argued that culture steers human evolution, while others proposed that genes hold culture on a leash. We review the literature and evidence on long-term GCC in humans and find a set of common themes.

First, culture appears to hold greater adaptive potential than genetic inheritance and is probably driving human evolution. The evolutionary impact of culture occurs mainly through culturally organized groups, which have come to dominate human affairs in recent millennia. Second, the role of culture appears to be growing, increasingly bypassing genetic evolution and weakening genetic adaptive potential. Taken together, these findings suggest that human long-term GCC is characterized by an evolutionary transition in inheritance (from genes to culture) which entails a transition in individuality (from genetic individual to cultural group). Thus, research on GCC should focus on the possibility of an ongoing transition in the human inheritance system.

Anthropology and the study of contradictions

Contradictions constitute one fundamental aspect of human life. Humans are steeped in contradictory thoughts, feelings, and attitudes. In this debate, five anthropologists adopt an individual-centered and phenomenological perspective on contradictions. How can one live with them? How to describe them from an anthropological point of view? Should we rethink our dear notion of the “social agent” through that of contradiction?

Anthropology will only matter if it evokes a purpose outside of itself

Seven elements that anthropology can provide: (1) Gap between Here & Elsewhere, (2) Question Universal Claims, (3) Border between Humanities & Social Sciences, (4) Addressing Rise of the Financiers, (5) Dispelling Savage Illusions, (6) Relations & Processes, not Essences

Top-down causation in psychiatric disorders: a clinical-philosophical inquiry

Psychiatry has long debated whether the causes of mental illness can be better explained by reductionist or pluralistic accounts. Although the former relies on commonsense scientific bottom-up causal models, the latter (which typically include environmental, psychological, and/or socio-cultural risk factors) requires top-down causal processes often viewed with skepticism, especially by neuroscientists. We begin with four clinical vignettes which illustrate self-interventions wherein high-order psychological processes (e.g. religious beliefs or deep interpersonal commitments) appear to causally impact the risk for or the course of psychiatric/behavioral disorders.

We then propose a model for how to understand this sort of top-down self-causation. Our model relies centrally on the concept of a control variable which, like a radio tuning dial, can implement a series of typically unknown physical processes to obtain the desired ends. We set this control variable in the context of an interventionist account of causation that assumes that a cause (C) produces an effect (E) when intervening on C (by manipulating it) is associated with a change in E. We extend this framework by arguing that certain psychological changes can result from individuals intervening on their own mental states and/or selection of environments. This in turn requires a conception of the self that contains mental capacities that are at least partially independent of one another. Although human beings cannot directly intervene on the neurobiological systems which instantiate risk for psychiatric illness, they can, via control variables at the psychological level, and/or by self-selection into protective environments, substantially alter their own risk.

Evaluating the Machine Learning Literature: A Primer and User’s Guide for Psychiatrists

“Mr. A,” a 24-year-old man, presents for evaluation of worsening depression. He describes a history of depression since adolescence, although he notes that he suffered a troubled childhood, including emotional neglect. He believes a recent breakup and having been denied a promotion precipitated this episode. “I’m sleeping all the time, and my body feels heavy,” he adds. He also reports increased appetite, weight gain, and “urges to cut, which I have not done in years.” However, he remains social and actively involved in several hobbies. He discontinued bupropion and escitalopram in the past because of “terrible headaches and irritability.” Initially, you consider starting lamotrigine. However, your office recently implemented a clinical decision support system that recommends a trial of phenelzine. The patient’s symptoms remit entirely on the medication suggested by the system. Curious as to how the system decided on this treatment, you download several papers on its development.

Cultural mosaics, social structure, and identity: The Acheulean threshold in Europe

The period between 600 and 400 ka is a critical phase for human evolution in Europe. The south and northwest saw a dramatic increase in sites, the spread of handaxe technology alongside bone and wooden tool manufacture, efficient hunting techniques, and the use of fire. Lithic assemblages show considerable variation, including the presence/absence of handaxes and tool morphology.

To explain this variation, we propose the Cultural Mosaic Model, which suggests that there is a range of expressions of the Acheulean, with local resources being instrumental in creating distinct material cultures with or without handaxes. We argue that if typologically and technologically distinct assemblage types are regionally distributed, chronologically separated, and persistent over time, then they are unlikely to be caused purely by raw material constraints or functional variation but rather reflect populations with different material cultures…

We suggest that group expression through material culture was an important stage in social development by promoting group cohesion, larger group size, better cooperation, improved knowledge transfer, and enabling populations to survive in larger foraging territories in northern Europe.

How did Neanderthals and other ancient humans learn to count?

In the light of these discoveries, D’Errico has developed a scenario to explain how number systems might have arisen through the very act of producing such artefacts. His hypothesis is one of only two published so far for the prehistoric origin of numbers.

It all started by accident, he suggests, as early hominins unintentionally left marks on bones while they were butchering animal carcasses. Later, the hominins made a cognitive leap when they realized that they could deliberately mark bones to produce abstract designs — such as those seen on an approximately 430,000-year-old shell found in Trinil, Indonesia6. At some point after that, another leap occurred: individual marks began to take on meaning, with some of them perhaps encoding numerical information. The Les Pradelles hyena bone is potentially the earliest known example of this type of mark-making, says D’Errico. He thinks that with further leaps, or what he dubs cultural exaptations, such notches eventually led to the invention of number signs such as 1, 2 and 3.

Cultural Exaptation and Cultural Neural Reuse: A Mechanism for the Emergence of Modern Culture and Behavior

On the basis of recent advancements in both neuroscience and archaeology, we propose a plausible biocultural mechanism at the basis of cultural evolution. The proposed mechanism, which relies on the notions of cultural exaptation and cultural neural reuse, may account for the asynchronous, discontinuous, and patchy emergence of innovations around the globe. Cultural exaptation refers to the reuse of previously devised cultural features for new purposes. Cultural neural reuse refers to cases in which exposure to cultural practices induces the formation, activation, and stabilization of new functional and/or structural brain networks during the individual lifespan.

The invention of writing is interpreted as a case of cultural exaptation of previous devices to record information, in use since at least the Early Later Stone Age and the beginning of the Upper Paleolithic (44,000 years before present). The measurable changes in brain structure and functioning caused by learning to read are proposed as an exemplar case of cultural neural reuse. It is argued that repeated cycles of cultural exaptation, development of appropriate strategies of cultural transmission, and ensuing cultural neural reuse represent the fundamental mechanism that has regulated the cultural evolution of our lineage.

Wednesday Round Up #52

Heat Listed

McDaniel was both a potential victim and a potential perpetrator, and the visitors on his porch treated him as such. A social worker told him that he could help him if he was interested in finding assistance to secure a job, for example, or mental health services. And police were there, too, with a warning: from here on out, the Chicago Police Department would be watching him. The algorithm indicated Robert McDaniel was more likely than 99.9 percent of Chicago’s population to either be shot or to have a shooting connected to him. That made him dangerous, and top brass at the Chicago PD knew it. So McDaniel had better be on his best behavior.

The idea that a series of calculations could predict that he would soon shoot someone, or be shot, seemed outlandish. At the time, McDaniel didn’t know how to take the news.

But the visit set a series of gears in motion. This Kafka-esque policing nightmare — a circumstance in which police identified a man to be surveilled based on a purely theoretical danger — would seem to cause the thing it predicted, in a deranged feat of self-fulfilling prophecy.

Ozzy Man Reviews: Elephant Seal Love Triangle

Here’s me commentary on a romantic entanglement involving Elephant Seals.

The computational cost of active information sampling before decision-making under uncertainty

Humans often seek information to minimize the pervasive effect of uncertainty on decisions. Current theories explain how much knowledge people should gather before a decision, based on the cost–benefit structure of the problem at hand. Here, we demonstrate that this framework omits a crucial agent-related factor: the cognitive effort expended while collecting information. Using an active sampling model, we unveil a speed–efficiency trade-off whereby more informative samples take longer to find. Crucially, under sufficient time pressure, humans can break this trade-off, sampling both faster and more efficiently.

Computational modelling demonstrates the existence of a cost of cognitive effort which, when incorporated into theoretical models, provides a better account of people’s behaviour and also relates to self-reported fatigue accumulated during active sampling. Thus, the way people seek knowledge to guide their decisions is shaped not only by task-related costs and benefits, but also crucially by the quantifiable computational costs incurred.

Professor John Krakauer On The Science Of Learning And Gamifying Neurological Repair And Rehab

Dr. Krakauer is currently John C. Malone Professor of Neurology, Neuroscience, and Physical Medicine and Rehabilitation, and Director of the Brain, Learning, Animation, and Movement Lab ( at The Johns Hopkins University School of Medicine. His areas of research interest are:

(1) Experimental and computational studies of motor control and motor learning in humans

(2) Tracking long-term motor skill learning and its relation to higher cognitive processes such as decision-making.

(3) Prediction of motor recovery after stroke

(4) Mechanisms of spontaneous motor recovery after stroke in humans and in mouse models

(5) New neuro-rehabilitation approaches for patients in the first 3 months after stroke.

Dr. Krakauer is also co-founder of the video gaming company Max and Haley, and of the creative engineering Hopkins-based project named KATA. KATA and M&H are both predicated on the idea that animal movement based on real physics is highly pleasurable and that this pleasure is hugely heightened when the animal movement is under the control of our own movements. A simulated dolphin and other cetaceans developed by KATA has led to a therapeutic game, interfaced with an FDA-approved 3D exoskeletal robot, which is being used in an ongoing multi-site rehabilitation trial for early stroke recovery. Dr. Krakauer’s book, “Broken Movement: The Neurobiology of Motor Recovery after Stroke” has been published by the MIT Press.

How the ‘Culture War’ Could Break Democracy

In this tangle between very powerful institutions and very powerful cultural logics, there are serious problems that are deeply rooted. The great democratic revolutions of Western Europe and North America were rooted in the intellectual and cultural revolution of Enlightenment; the Enlightenment underwrote those political transformations. If America’s hybrid Enlightenment underwrote the birth of liberal democracy in the United States, what underwrites it now?

What is going to underwrite liberal democracy in the 21st century? To me, it’s not obvious. That’s the big puzzle I’m working through right now. But it bears on this issue of culture wars, because if there’s nothing that we share in common—if there is no hybrid enlightenment that we share—then what are the sources we can draw upon to come together and find any kind of solidarity?

Sleep Evolved Before Brains. Hydras Are Living Proof.

But a counterpoint to this brain-centric view of sleep has emerged. Researchers have noticed that molecules produced by muscles and some other tissues outside the nervous system can regulate sleep. Sleep affects metabolism pervasively in the body, suggesting that its influence is not exclusively neurological. And a body of work that’s been growing quietly but consistently for decades has shown that simple organisms with less and less brain spend significant time doing something that looks a lot like sleep. Sometimes their behavior has been pigeonholed as only “sleeplike,” but as more details are uncovered, it has become less and less clear why that distinction is necessary.

It appears that simple creatures — including, now, the brainless hydra — can sleep. And the intriguing implication of that finding is that sleep’s original role, buried billions of years back in life’s history, may have been very different from the standard human conception of it. If sleep does not require a brain, then it may be a profoundly broader phenomenon than we supposed.

Just-in-Time Adaptive Interventions and Adaptive Interventions

Behavioral interventions for prevention and treatment are an important part of the fight against drug abuse and conditions such as HIV/AIDS and mental illness. Among the challenges faced by scientists is how and when to alter the course of treatment for participants in the intervention. Adaptive interventions (also known as “adaptive treatment strategies” or “dynamic treatment regimens”) change based on what is best for the patient at that time.

Just-in-time adaptive interventions (JITAIs) are a special type of adaptive intervention where—thanks to mobile technology like activity sensors and smartphones—an intervention can be delivered when and where it is needed.

Technically speaking, an adaptive intervention is a sequence of decision rules that specify how the intensity or type of treatment should change depending on the patient’s needs. Methodology Center researchers are developing data-analytic methods for constructing decision rules that allow researchers to build better JITAIs and adaptive interventions.

Seeds of economic health disparities found in subsistence society

For a study in the journal eLife, a research team led by Aaron Blackwell of Washington State University and Adrian Jaeggi of University of Zurich tracked 13 different health variables across 40 Tsimane communities, analyzing them against each person’s wealth and the degree of inequality in each community. While some have theorized that inequality’s health impacts are universal, the researchers found only two robustly associated outcomes: higher blood pressure and respiratory disease.

“The connection between inequality and health is not as straightforward as what you would see in an industrialized population. We had a lot of mixed results,” said Blackwell, a WSU associate professor of anthropology. “These findings suggest that at this scale, inequality is not at the level that causes health problems. Instead maybe it’s the extreme inequality in a lot of modern environments that causes health problems since it’s unlike any inequality we’ve ever had in our evolutionary history.”

The War on Critical Race Theory

What do all these attacks add up to? The exact targets of CRT’s critics vary wildly, but it is obvious that most critics simply do not know what they are talking about. Instead, CRT functions for the right today primarily as an empty signifier for any talk of race and racism at all, a catch-all specter lumping together “multiculturalism,” “wokeism,” “anti-racism,” and “identity politics”—or indeed any suggestion that racial inequities in the United States are anything but fair outcomes, the result of choices made by equally positioned individuals in a free society. They are simply against any talk, discussion, mention, analysis, or intimation of race—except to say we shouldn’t talk about it.

Wednesday Round Up #51

“The Descent of Man,” 150 years on

“The Descent of Man” is one of the most influential books in the history of human evolutionary science. We can acknowledge Darwin for key insights but must push against his unfounded and harmful assertions. Reflecting on “Descent” today one can look to data demonstrating unequivocally that race is not a valid description of human biological variation, that there is no biological coherence to “male” and “female” brains or any simplicity in biological patterns related to gender and sex, and that “survival of the fittest” does not accurately represent the dynamics of evolutionary processes.

The scientific community can reject the legacy of bias and harm in the evolutionary sciences by recognizing, and acting on, the need for diverse voices and making inclusive practices central to evolutionary inquiry. In the end, learning from “Descent” illuminates the highest and most interesting problem for human evolutionary studies today: moving toward an evolutionary science of humans instead of “man.”

No support for the hereditarian hypothesis of the Black–White achievement gap using polygenic scores and tests for divergent selection

Tests for selection using polygenic scores failed to find evidence of natural selection when the less biased within-family GWAS effect sizes were used. Tests for selection using Fst values did not find evidence of natural selection. Expected mean difference in IQ was substantially smaller than postulated by hereditarians, even under unrealistic assumptions that overestimate genetic contribution.
Given these results, hereditarian claims are not supported in the least. Cognitive performance does not appear to have been under diversifying selection in Europeans and Africans. In the absence of diversifying selection, the best case estimate for genetic contributions to group differences in cognitive performance is substantially smaller than hereditarians claim and is consistent with genetic differences contributing little to the Black–White gap.

What critical race theory is really about

As critical race theory becomes increasingly politicized and attacked by Republicans, CNN’s Jason Carroll explains what the concept is, and what it isn’t.

What Will It Take to Stop Swimming in the Waters of Racism?

The Southern African concept of ubuntu offers a crucial lesson for the U.S.: By recognizing our interconnections and actively undoing systemic racism, we can all become more fully human.

The miracle of the commons

Even before Hardin’s ‘The Tragedy of the Commons’ was published, however, the young political scientist Elinor Ostrom had proven him wrong. While Hardin speculated that the tragedy of the commons could be avoided only through total privatisation or total government control, Ostrom had witnessed groundwater users near her native Los Angeles hammer out a system for sharing their coveted resource. Over the next several decades, as a professor at Indiana University Bloomington, she studied collaborative management systems developed by cattle herders in Switzerland, forest dwellers in Japan, and irrigators in the Philippines. These communities had found ways of both preserving a shared resource – pasture, trees, water – and providing their members with a living. Some had been deftly avoiding the tragedy of the commons for centuries; Ostrom was simply one of the first scientists to pay close attention to their traditions, and analyse how and why they worked.

The features of successful systems, Ostrom and her colleagues found, include clear boundaries (the ‘community’ doing the managing must be well-defined); reliable monitoring of the shared resource; a reasonable balance of costs and benefits for participants; a predictable process for the fast and fair resolution of conflicts; an escalating series of punishments for cheaters; and good relationships between the community and other layers of authority, from household heads to international institutions.

Circular Economies & Regenerative Cultures

A common mistake is to speak and think of ‘circular economy’ or ‘regenerative culture’ as a singular. Such thinking is informed by the profoundly un-ecological neoliberal economic doctrine of ‘scaling-up’ and ‘globalising’. To create human economic and industrial patterns that fit into the way life sustains ecosystems and planetary health we need to co-create diverse circular economies in service of diverse regenerative cultures. The underlying patterns and principles might be the same, yet the place-sourced expressions of these will be unique adaptations to the bio-cultural uniqueness of their bioregional context.

Safety is fatal: On the dynamics of social trust in human cultures

Finally, do human colonies on the wane also become increasingly less capable of differentiation? We know that, when human societies feel threatened, they protect themselves: they zero in on short-term gains, even at the cost of their long-term futures. And they scale up their ‘inclusion criteria’. They value sameness over difference; stasis over change; and they privilege selfish advantage over civic sacrifice.

Viewed this way, the comparison seems compelling. In crisis, the colony introverts; collapsing inwards as inequalities escalate and there’s not enough to go around. In a crisis, as we’ve seen during the COVID-19 pandemic, people define ‘culture’ more aggressively, looking for alliances in the very places where they can invest their threatened social trust; for the centre is threatened and perhaps ‘cannot hold’.

Human cultures, like cell cultures, are not steady states. They can have split purposes as their expanding and contracting concepts of insiders and outsiders shift, depending on levels of trust, and on the relationship between available resources and how many people need them. Trust, in other words, is not only related to moral engagement, or the health of a moral economy. It’s also dependent on the dynamics of sharing, and the relationship of sharing practices to group size – this last being a subject that fascinates anthropologists.

What Happens to Our Brains When We Get Depressed?

The disease affects more than 260 million people around the world, but we barely understand it. We know that the balance between the prefrontal cortex (at the front of the brain) and the anterior cingulate cortex (tucked just behind it) plays some role in regulating mood, as does the chemical serotonin. But what actually causes depression? Is there a tiny but important area of the brain that researchers should focus on? And does there even exist a singular disorder called depression, or is the label a catch-all denoting a bunch of distinct disorders with similar symptoms but different brain mechanisms? “Fundamentally,” says Hill, “we don’t have a biological understanding of depression or any other mental illness.”

The problem, for Hill, requires an ambitious, participatory approach. If neuroscientists are to someday understand the biological mechanisms behind mental illness—that is, if they are to figure out what literally happens in the brain when a person is depressed, manic, or delusional—they will need to pool their resources. “There’s not going to be a single person who figures it all out,” he says. “There’s never going to be an Einstein who solves a set of equations and shouts, ‘I’ve got it!’ The brain is not that kind of beast.”

Neural integration underlying naturalistic prediction flexibly adapts to varying sensory input rate

Prediction of future sensory input based on past sensory information is essential for organisms to effectively adapt their behavior in dynamic environments. Humans successfully predict future stimuli in various natural settings. Yet, it remains elusive how the brain achieves effective prediction despite enormous variations in sensory input rate, which directly affect how fast sensory information can accumulate. We presented participants with acoustic sequences capturing temporal statistical regularities prevalent in nature and investigated neural mechanisms underlying predictive computation using MEG.

By parametrically manipulating sequence presentation speed, we tested two hypotheses: neural prediction relies on integrating past sensory information over fixed time periods or fixed amounts of information. We demonstrate that across halved and doubled presentation speeds, predictive information in neural activity stems from integration over fixed amounts of information. Our findings reveal the neural mechanisms enabling humans to robustly predict dynamic stimuli in natural environments despite large sensory input rate variations.


Influential groups for seeding and sustaining hypergraph contagions

Several biological and social contagion phenomena, such as superspreading events or social reinforcement, are the results of multi-body interactions, for which hypergraphs offer a natural mathematical description. In this paper, we develop a novel mathematical framework based on approximate master equations to study contagions on random hypergraphs with a heterogeneous structure, both in terms of group size (hyperedge cardinality) and of membership of nodes to groups (hyperdegree). The characterization of the inner dynamics of groups provides an accurate description of the contagion process, without losing the analytical tractability. Using a contagion model where multi-body interactions are mapped onto a nonlinear infection rate, our two main results show how large groups are influential, in the sense that they drive both the early spread of a contagion and its endemic state (i.e., its stationary state).

First, we provide a detailed characterization of the phase transition, which can be continuous or discontinuous with a bistable regime, and derive analytical expressions for the critical and tricritical points. We find that large values of the third moment of the membership distribution suppress the emergence of a discontinuous phase transition. Furthermore, the combination of heterogeneous group sizes and nonlinear contagion facilitates the onset of a mesoscopic localization phase, where contagion is sustained only by the largest groups, thereby inhibiting bistability as well. Second, we formulate a simple problem of optimal seeding for hypergraph contagions to compare two strategies: tuning the allocation of seeds according to either node individual properties or according to group properties. We find that, when the contagion is sufficiently nonlinear, groups are more effective seeds of contagion than individual nodes.

Frequency Effects on Memory: A Resource-Limited Theory

We present a review of frequency effects in memory, accompanied by a theory of memory, according to which the storage of new information in long-term memory (LTM) depletes a limited pool of working memory (WM) resources as an inverse function of item strength. We support the theory by showing that items with stronger representations in LTM (e.g., high frequency items) are easier to store, bind to context, and bind to one another; that WM resources are involved in storage and retrieval from LTM; that WM performance is better for stronger, more familiar stimuli.

We present a novel analysis of preceding item strength, in which we show from nine existing studies that memory for an item is higher if during study it was preceded by a stronger item (e.g., a high frequency word). This effect is cumulative (the more prior items are of high frequency, the better), continuous (memory proportional to word frequency of preceding item), interacts with current item strength (larger for weaker items), and interacts with lag (decreases as the lag between the current and prior study item increases). A computational model that implements the theory is presented, which accounts for these effects. We discuss related phenomena that the model/theory can explain.

Experience replay is associated with efficient nonlocal learning

Learning from direct experience is easy—we can always use trial and error—but how do we learn from nondirect (nonlocal) experiences? For this, we need additional mechanisms that bridge time and space. In rodents, hippocampal replay is hypothesized to promote this function. Liu et al. measured high-temporal-resolution brain signals using human magnetoencephalography combined with a new model-based, visually oriented, multipath reinforcement memory task. This task was designed to differentiate local versus nonlocal learning episodes within the subject. They found that reverse sequential replay in the human medial temporal lobe supports nonlocal reinforcement learning and is the underlying mechanism for solving complex credit assignment problems such as value learning.

Principles and open questions in functional brain network reconstruction

Graph theory is now becoming a standard tool in system-level neuroscience. However, endowing observed brain anatomy and dynamics with a complex network representation involves often covert theoretical assumptions and methodological choices which affect the way networks are reconstructed from experimental data, and ultimately the resulting network properties and their interpretation. Here, we review some fundamental conceptual underpinnings and technical issues associated with brain network reconstruction, and discuss how their mutual influence concurs in clarifying the organization of brain function.

Two views on the cognitive brain

Cognition can be defined as computation over meaningful representations in the brain to produce adaptive behaviour. There are two views on the relationship between cognition and the brain that are largely implicit in the literature. The Sherringtonian view seeks to explain cognition as the result of operations on signals performed at nodes in a network and passed between them that are implemented by specific neurons and their connections in circuits in the brain.

The contrasting Hopfieldian view explains cognition as the result of transformations between or movement within representational spaces that are implemented by neural populations. Thus, the Hopfieldian view relegates details regarding the identity of and connections between specific neurons to the status of secondary explainers. Only the Hopfieldian approach has the representational and computational resources needed to develop novel neurofunctional objects that can serve as primary explainers of cognition.

Wednesday Round Up #50

Play vocalisations and human laughter: a comparative review

Complex social play is well-documented across many animals. During play, animals often use signals that facilitate beneficial interactions and reduce potential costs, such as escalation to aggression. Although greater focus has been given to visual play signals, here we demonstrate that vocalisations constitute a widespread mode of play signalling across species.

Our review indicates that vocal play signals are usually inconspicuous, although loud vocalisations, which suggest a broadcast function, are present in humans and some other species. Spontaneous laughter in humans shares acoustic and functional characteristics with play vocalisations across many species, but most notably with other great apes. Play vocalisations in primates and other mammals often include sounds of panting, supporting the theory that human laughter evolved from an auditory cue of laboured breathing during play.

Human social complexity allowed laughter to evolve from a play-specific vocalisation into a sophisticated pragmatic signal that interacts with a large suite of other multimodal social behaviours in both intragroup and intergroup contexts. This review provides a foundation for detailed comparative analyses of play vocalisations across diverse taxa, which can shed light on the form and function of human laughter and, in turn, help us better understand the evolution of human social interaction.

Madalina Vlasceanu PhD defense, Princeton University

Cognitive Processes Shaping Individual and Collective Belief Systems, a PhD defense in the Departments of Psychology and Neuroscience at Princeton University

The Power and Pitfalls of Gamification

Technology companies like Cisco, Microsoft, and SAP, for instance, found ways to gamify everything from learning social media skills, to verifying language translations, to boosting sales performance.

Today, thanks to science, we know a lot more about when gamification really works, and what its boundaries seem to be. Beyond the gamified apps and software we use to learn new skills, companies like Amazon and Uber now deploy it to boost worker productivity. But to get the results we seek, in our own lives and in the workplace, it’s important to understand when gamification will work—and when it will only make matters worse…

My colleagues argue that their study highlights a common mistake companies make with gamification: Gamification is unhelpful and can even be harmful if people feel that their employer is forcing them to participate in “mandatory fun.” Another issue is that if a game is a dud, it doesn’t do anyone any good. Gamification can be a miraculous way to boost engagement with monotonous tasks at work and beyond, or an over-hyped strategy doomed to fail. What matters most is how the people playing the game feel about it…

At its best, gamification seems to work when it helps people achieve the goals they want to reach anyway by making the process of goal achievement more exciting. When people fully buy into a game, the results can be impressive, durably improving volunteers’ productivity, boosting worker morale, and even, as seen in one recent study, robustly helping families increase their step counts. But gamification can tank when players don’t buy in. If a game is mandatory and designed to encourage people to do something they don’t particularly care to do (like achieving an outstanding record of attendance at school), or if it feels manipulative, it can backfire.

Big Blue Lotus Brain – original watercolor painting – neuroscience art

This painting draws together images from neuroscience (neural connections in the brain) and Buddhism (the lotus), to express the blissful aura of the well-meditated brain. Recent scientific research indicates that the practice of meditation produces physical changes in parts of the brain associated with memory, sense of self, empathy and stress. Although it’s highly unlikely that meditating on the truth in the lotus will actually cause your neurons to look like this, it’s a fun idea to express artistically. In soft but vivid shades of blue, from cerulean to indigo.

The Reincarnated

The scientist prodded his Burmese interview subject, whose name was Ma Tin Aung Myo, for details about the Japanese soldier she described dying near that spot many years earlier, years before Ma Tin was born. She proceeded to tell the scientist from America facts about the dead man’s life she shouldn’t have known. Her claim was outrageous and dangerous, and yet, as she unfolded the dead man’s story, she was unequivocal: She was that soldier, the reincarnation of a man cut down in his prime by enemy bullets.

Professor Ian Stevenson leaned into his questions, pressing her, daring her. He needed a breakthrough, with his credibility and standing at his university on the brink. His life’s work might not recover otherwise. Ma Tin Aung Myo, the young woman with the short haircut and baggy clothes answered his questions gamely. Then her demeanor changed. Looking the scientist square in the eyes, she issued a shocking request in Burmese.

What cats’ love of boxes and squares can tell us about their visual perception

The paper was inspired in part by a 2017 viral Twitter hashtag, #CatSquares, in which users posted pictures of their cats sitting inside squares marked out on the floor with tape—kind of a virtual box. The following year, lead author Gabriella Smith, a graduate student at Hunter College (CUNY) in New York City, attended a lecture by co-author Sarah-Elizabeth Byosiere, who heads the Thinking Dog Center at Hunter. Byosiere studies canine behavior and cognition, and she spoke about dogs’ susceptibility to visual illusions. While playing with her roommate’s cat later that evening, Smith recalled the Twitter hashtag and wondered if she could find a visual illusion that looked like a square to test on cats.

Smith found it in the work of the late Italian psychologist and artist Gaetano Kanizsa, who was interested in illusory (subjective) contours that visually evoke the sense of an edge in the brain even if there isn’t really a line or edge there. The Kanizsa square consists of four objects shaped like Pac-Man, oriented with the “mouth” facing inward to form the four corners of a square. Even better, there was a 1988 study that used the Kanizsa square to investigate the susceptibility of two young female cats to illusory contours. The study concluded that, yes, cats are susceptible to the Kanizsa square illusion, suggesting that they perceive subjective contours much like humans.

Scan Once, Analyse Many: Using Large Open-Access Neuroimaging Datasets to Understand the Brain

We are now in a time of readily available brain imaging data. Not only are researchers now sharing data more than ever before, but additionally large-scale data collecting initiatives are underway with the vision that many future researchers will use the data for secondary analyses. Here I provide an overview of available datasets and some example use cases. Example use cases include examining individual differences, more robust findings, reproducibility–both in public input data and availability as a replication sample, and methods development. I further discuss a variety of considerations associated with using existing data and the opportunities associated with large datasets. Suggestions for further readings on general neuroimaging and topic-specific discussions are also provided.

The Biology of Coffee, One of the World’s Most Popular Drinks

Coffee won’t cure cancer, but it may help to prevent it and possibly other diseases as well. Part of answering the question of coffee’s connection to cancer lies in asking another: what is cancer? At its simplest, cancer is uncontrolled cell growth, which is fundamentally about regulating when genes are, or are not, actively expressed.

My research group studies gene regulation and I can tell you that even a good cup of coffee, or boost of caffeine, won’t cause genes that are turned off or on at the wrong time to suddenly start playing by the rules.

The antioxidants in coffee may actually have a cancer-fighting effect. Remember that antioxidants fight cellular damage. One type of damage that they may help reduce is mutations to DNA, and cancer is caused by mutations that lead to the misregulation of genes.

Dances with whales: the ethereal underwater vistas of an elite freediving team

One Breath Around the World is the latest aquatic spectacle from the French freediving champion Guillaume Néry, and his partner, the French freediver, underwater filmmaker and dancer Julie Gautier. Without the aid of supplied air, Néry plunges into the ocean’s hidden depths, revealing remarkable views of marine geology and wildlife around the globe. Seamlessly transitioning between a range of underwater realms, the video gives the impression that Néry’s journey is taken in a single breath. With stunning camerawork by Gautier, who also held her breath while filming, the duo prove themselves expert explorers of not only water, but space and perspective as well, making these grand underwater landscapes appear almost alien.

Tooth plaque from ancient skeleton offers new insight into human evolution

Their most significant finding is one group of bacteria present in both modern humans and Neanderthals is specifically adapted to consume starch. This suggests starchy foods such as roots, tubers and seeds became important in the human diet long before the introduction of farming. Some researchers believe the transition to eating these starchy foods, which are rich in energy, may have enabled humans to grow the large brains that characterize our species.

“Understanding the role that food played in the evolutionary development of human uniqueness is complicated because many types of food remains — especially plants — are poorly preserved in the fossil record,” said John Yellen, director of the National Science Foundation’s archaeology and archaeometry program, which supported the research. “This innovative study of ancient bacteria preserved in fossil plaque provides a new and powerful way to understand the evolution of humans and our social and ecological history.”

This Is Your Brain on Exercise

Your brain becomes much more active during exercise, “perhaps more active than at any other time,” says Maddock. One way neurons communicate is with electrical pulses, and sometimes entire networks of neurons fire in unison, like a group of soccer fans chanting together at a game. These synchronized pulses are known colloquially as brain waves. Different kinds of brain waves, characterized by the number of times they oscillate in a single second, are linked to one’s mental state and mood. Lower-frequency waves occur when we’re running on autopilot: brushing our teeth, driving, or sleeping, for example. Higher-frequency waves, known as beta waves, occur when we’re awake and mentally engaged and are associated with attention, memory, and information processing.

Using tools like an electroencephalogram (EEG), which pick up on these electrical pulses, researchers have found that aerobic exercise causes a shift in the amplitude and frequency of brain waves. More beta waves, in other words, means that exercisers may be in a more alert state. “The brain is in a different gear when the human being is in motion,” Maddock says.

Wednesday Round Up #49

The Challenges of Animal Translation: Artificial intelligence may help us decode animalese. But how much will we really be able to understand?

Magnasco doesn’t think that anyone has achieved a basic understanding of dolphish. “I’m not yet confident that I know what is the signal, what is the variation, what is the intention,” he said. “You need an extremely large body of data to do that, and it’s unclear that we have enough yet.” Still, there are hints that it might be possible. In 2013, Herzing and her team at the Wild Dolphin Project used a machine-learning algorithm called Cetacean Hearing and Telemetry (CHAT), designed to identify meaningful signals in dolphin whistles. The algorithm picked out a sound within a dolphin pod that the researchers had earlier trained the dolphins to associate with sargassum seaweed—a clumpy, floaty plant that dolphins sometimes play with. The dolphins may have assimilated the new “word,” and begun using it in the wild.

And yet, in an important sense, dolphish may be more than a language. Dolphins don’t just make whistles—they also employ body language and a variety of sounds, including clicks, which they use for sonar echolocation. From the acoustic reflections created by the clicks, a dolphin can form a mental picture of an object’s size, shape, and density. Dolphins can interpret one another’s sonar signals. “They are able to see shapes of things when they passively eavesdrop on someone else’s clicks,” Magnasco said. Using sound alone, they can see what another sees…

Britt Selvitelle, a computer scientist who worked on the team that created Twitter, is a founding member of the Earth Species Project, an organization founded in San Francisco that is developing A.I. approaches like this to animal communication. “We’re working on decoding the first nonhuman language,” he said, at the M.I.T. workshop—a goal that he thinks can be reached in five to ten years. In theory, a machine-learning system is particularly well suited to the problem of translating animalese. The loose correspondences between human and animal words and concepts may not matter to an A.I.; neither will the fact that animal ideas may be expressed not as vocalizations but as gestures, sequences of movements, or changes in skin texture. A neural network makes no assumptions about the nature of the input data; as long as there is some aspect of an animal’s behavioral repertoire that represents or expresses something that our languages can also express—a type of species, a warning, a spatial direction—then the algorithm has a chance of spotting it. “We’re really asking people to remove their human glasses, as much as possible,” Selvitelle said. One Earth Species Project collaboration, called Whale-X, aims to collect and analyze all communications among a pod of whales over an entire season.

2021 USF WLP Faculty Excellence Award Recipients
Heather O’Leary on her work on water, agency, and gender

Brain size and neuron numbers drive differences in yawn duration across mammals and birds

Recent studies indicate that yawning evolved as a brain cooling mechanism. Given that larger brains have greater thermolytic needs and brain temperature is determined in part by heat production from neuronal activity, it was hypothesized that animals with larger brains and more neurons would yawn longer to produce comparable cooling effects. To test this, we performed the largest study on yawning ever conducted, analyzing 1291 yawns from 101 species (55 mammals; 46 birds). Phylogenetically controlled analyses revealed robust positive correlations between yawn duration and (1) brain mass, (2) total neuron number, and (3) cortical/pallial neuron number in both mammals and birds, which cannot be attributed solely to allometric scaling rules. These relationships were similar across clades, though mammals exhibited considerably longer yawns than birds of comparable brain and body mass. These findings provide further evidence suggesting that yawning is a thermoregulatory adaptation that has been conserved across amniote evolution.

The Brain–Cognitive Behavior Problem: A Retrospective

In 2001, I was invited to write a review for a prominent journal. I thought that the best way to exploit this opportunity was to write an essay about my problems with ill-defined scientific terms and question whether the dominant framework in neuroscience is on the right track. My main argument was that many terms in neuroscience are inherited from folk psychology and are often used in two ambiguous ways: both as the thing-to-be-explained (explanandum) and the thing-that-explains (explanans; e.g., “we have memory because we remember,” “we remember because we have memory”). These postulated terms are assumed to be entities with definable boundaries, and within this framework, the goal of neuroscience is to find homes and mechanisms for these terms in the brain with corresponding boundaries (I called this “the correlational approach”). I warned that a framework dictated by human-centric introspection might not be the right roadmap for neuroscience and argued that there should be another way of carving up the brain’s “natural kinds.”

The Smartest Way To Get Lean In 2021 (Shredding Science Explained)
The first part on the “fat loss fundamentals” is solid. “You need to be in an energy deficit…”

In this video I’m asking 5 diet experts about the most effective science-based strategies for losing fat and keeping muscle.

The harmful ableist language you unknowingly use

This kind of ‘ableist’ language is omnipresent in conversation: making a “dumb” choice, turning a “blind eye” to a problem, acting “crazy”, calling a boss “psychopathic”, having a “bipolar” day. And, for the most part, people who utter these phrases aren’t intending to hurt anyone – more commonly, they don’t have any idea they’re engaging in anything hurtful at all.

However, for disabled people like me, these common words can be micro-assaults. For instance, “falling on deaf ears” provides evidence that most people associate deafness with wilful ignorance (even if they consciously may not). But much more than individual slights, expressions like these can do real, lasting harm to the people whom these words and phrases undermine – and even the people who use them in daily conversation, too…

No, You Are Not Addicted to Your Digital Device, But You May Have a Habit You Want to Break

It’s a mistake, however, to equate frequent social media use with addiction. Just the label carries stigma – a personal failing or pathology that has significant negative outcomes to the user and their family, such as lost jobs and destroyed relationships.

As researchers who study habits and social media use, we have found that excessive social media use can be a very strong habit. But that doesn’t make it an addiction.

Featured article: Yvan Prkachin on the origins of neuroscience

GREEN: Your essay focuses on brain science unification efforts at the Montreal Neurological Institute and the Massachusetts Institute of Technology. Could you briefly describe what drew you to this history and your process for finding relevant archival sources?

PRKACHIN: I had, for quite some time, been fascinated by the character of Wilder Penfield, the neurosurgeon who launched the MNI in the 1930s. (I grew up in Canada, and Penfield was a fairly well-known historical figure among my generation, thanks largely to a series of “Heritage Minute” short films commissioned by the Canadian government in the 1990s.) When I began working on my Ph.D. at Harvard in 2012, I knew that I was interested in Penfield and his institute, but I wasn’t quite sure what was most historically relevant about it, or where to place it in the broader history of the modern biomedical sciences. I was lucky enough to get a small grant in 2014 and spent nearly a year in Montreal rummaging through Penfield’s papers, and those of his collaborators; the men and women who worked at the MNI seemed to throw almost nothing away, so the records at the Osler Library for the History of Medicine and the McGill University Archives are incredibly rich.

Hasson Lab: The Hasson Lab attempts to develop complementary paradigms to study the neural activity that drives human behavior under natural and realistic conditions.

Our research shows that during continuous natural input, memory of past events influences online cortical activity. We call this type of influence “process memory,” defined as active traces of past information that are used by a neural circuit to process incoming information in the present moment (Hasson et al., TiCS 2015). Neural processes are defined as dynamic changes of the underlying brain states necessary for synthesizing information to guide behavior. Process memory has a clear hierarchical organization, in which its timescales gradually increase from early sensory areas that integrate over tens to hundreds of milliseconds to higher-order areas that integrate over many seconds to minutes.

Project Ecosystem: Mapping the Global Mental Health Research Funding System

To support the coordination of mental health research, RAND Europe mapped the research funding ‘ecosystem’. Researchers explored who the major funders are, what kinds of research they support, and how their strategies relate to one another.

The field of mental health research is large and growing, and opportunities include increasing collaboration, developing shared definitions, capitalising on government priorities, developing a key role for non-governmental funders and the advance of technology.

Why should you love squirrels? Here are six reasons

2. They are nature’s gardeners.

Squirrels have an important ecological role, especially in forest ecosystems, McCleery said.

“Their biggest contribution to the forest is in shaping plant composition. They have a peculiar habit of taking seeds, which are their main source of nutrients, and burying them. They bury them throughout the environment, and often, when they go back and look for them, they forget where they are. When that happens, they are effectively planting seeds,” McCleery said.

Over time, this behavior, called caching, changes the composition of a forest.

“They will expand forests and change the types of trees that are there,” he said. In Florida, for example, they have an important role of maintaining the native long-leaf pine ecosystem, McCleery said.

How to Turn Off Harmful Stress Like a Switch
Written in a popular style, but covers some of the basics well. And I don’t personally like the switch metaphor, but it makes for a catchy title (that ends up being really misleading…)

A classic study of two rats (journal article by D.L Helmreich et al) reveals an important insight about the role control plays in the experience of stress. The two rats are in separate cages connected to the same electrical circuit. The circuit administers random shocks through the metal floor of their cage. One rat has a lever in its cage that enables it to turn off the shocks while the other rat does not.

The rat with the lever in its cage is called “the executive rat,” because it has control. It has the power to turn off the electric current flowing through the cage. The rat with no control is called the “subordinate rat.”

When the experiment begins, both the executive rat and the subordinate rat show signs of stress, indicated by a sudden surge of the stress hormone, cortisol. Then, something interesting happens. The executive rat’s stress levels drop back to normal, while the subordinate rat’s stress remains high. Why? In a word, control.

‘It’s a Superpower’: How Walking Makes Us Healthier, Happier and Brainier

We are wandering the streets of Dublin discussing O’Mara’s book, In Praise of Walking, a backstage tour of what happens in our brains while we perambulate. Our jaunt begins at the grand old gates of his workplace, Trinity College, and takes in the Irish famine memorial at St Stephen’s Green, the Georgian mile, the birthplace of Francis Bacon, the site of Facebook’s new European mega-HQ and the salubrious seaside dwellings of Sandymount.

O’Mara, 53, is in his element striding through urban landscapes – from epic hikes across London’s sprawl to more sedate ambles in Oxford, where he received his DPhil – and waxing lyrical about science, nature, architecture and literature. He favours what he calls a “motor-centric” view of the brain – that it evolved to support movement and, therefore, if we stop moving about, it won’t work as well.

Wednesday Round Up #48

mHealth Training Institute Lectures

Our healthcare challenges are very complex and do not fit neatly into existing scientific disciplines; solving them requires the combined expertise and efforts of many scientific and technical disciplines. The NIH mHealth Training Institute (mHTI) was created to serve as an incubator for developing transdisciplinary scientists capable of co-creating mHealth solutions for “wicked” healthcare problems.

As one earlier example, Lisa Marsch — Changing Behavior

Lisa Marsch, Ph.D., speaks at the mHealth Training Institute 2015 (mHTI) on “Changing Behavior.” Dr. Marsch is Associate Professor of Psychiatry and Director, Center for Technology and Behavioral Health at Dartmouth College.

There is also a MD2K Webinar series that is part of the Training Core of the MD2K Center. These webinars are part of the curriculum that MD2K is providing to students in both data science and the biomedical disciplines to further the process of building the next generation of scientists capable of using these highly sophisticated biomedical applications.

Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?

There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. blood plasma levels of inflammatory markers, genetic mutations in immune pathways, viral or bacterial infection) with the development of neuropsychiatric conditions such as autism, bipolar disorder, schizophrenia and depression. A fundamental question remains open: why are psychiatric disorders and immune responses intertwined? To address this would require a step back from a historical mind–body dualism that has created such a dichotomy. We propose three contributions of active inference when addressing this question: translation, unification, and simulation.

To illustrate these contributions, we consider the following questions. Is there an immunological analogue of sensory attenuation? Is there a common generative model that the brain and immune system jointly optimise? Can the immune response and psychiatric illness both be explained in terms of self-organising systems responding to threatening stimuli in their external environment, whether those stimuli happen to be pathogens, predators, or people? Does false inference at an immunological level alter the message passing at a psychological level (or vice versa) through a principled exchange between the two systems?

The thalamus integrates the macrosystems of the brain to facilitate complex, adaptive brain network dynamics

The human brain is a complex, adaptive system comprised of billions of cells with trillions of connections. The interactions between the elements of the system oppose this seemingly limitless capacity by constraining the system’s dynamic repertoire, enforcing distributed neural states that balance integration and differentiation. How this trade-off is mediated by the brain, and how the emergent, distributed neural patterns give rise to cognition and awareness, remains poorly understood.

Here, I argue that the thalamus is well-placed to arbitrate the interactions between distributed neural assemblies in the cerebral cortex. Different classes of thalamocortical connections are hypothesized to promote either feed-forward or feedback processing modes in the cerebral
cortex. This activity can be conceptualized as emerging dynamically from an evolving attractor landscape, with the relative engagement of distinct distributed circuits providing differing constraints over the manner in which brain state trajectories change over time.
In addition, inputs to the distinct thalamic populations from the cerebellum and basal ganglia, respectively, are proposed to differentially shape the attractor landscape, and hence, the temporal evolution of cortical assemblies. The coordinated engagement of these neural macrosystems is then shown to share key characteristics with prominent models of cognition, attention and conscious awareness. In this way, the crucial role of the thalamus in mediating the distributed, multi-scale network organization of the central nervous system can be related to higher brain function.

Resynthesizing behavior through phylogenetic refinement

This article proposes that biologically plausible theories of behavior can be constructed by following a method of “phylogenetic refinement,” whereby they are progressively elaborated from simple to complex according to phylogenetic data on the sequence of changes that occurred over the course of evolution. It is argued that sufficient data exist to make this approach possible, and that the result can more effectively delineate the true biological categories of neurophysiological mechanisms than do approaches based on definitions of putative functions inherited from psychological traditions.

As an example, the approach is used to sketch a theoretical framework of how basic feedback control of interaction with the world was elaborated during vertebrate evolution, to give rise to the functional architecture of the mammalian brain. The results provide a conceptual taxonomy of mechanisms that naturally map to neurophysiological and neuroanatomical data and that offer a context for defining putative functions that, it is argued, are better grounded in biology than are some of the traditional concepts of cognitive science.

Why a Nepali doctor is treating the biology — and the sociology — behind mental illness

The focus on the brain in mental health research today is understandable. A person with a broken leg probably won’t hesitate to see a doctor, but the median time from first psychosis to psychiatric care in the U.S. is 74 weeks. Perhaps, the logic goes, a broken-brain model will shift responsibility from the person to the organ.

But there is no evidence that reframing mental illnesses as brain disorders reduces the associated stigma. Wherever doctors describe someone with a mental illness as having a chemical imbalance or abnormal brain circuitry, they provide reasons to fear that person. A German survey showed that the more people learned about the biology of mental illnesses, the more they reported a desire for social distance from people with a psychiatric diagnosis. A U.S. study showed that from 1996 to 2006, the American public increasingly saw mental illnesses as neurobiological, but this did not “significantly lower odds of stigma.”

Addiction as a brain disease revised: why it still matters, and the need for consilience

The view that substance addiction is a brain disease, although widely accepted in the neuroscience community, has become subject to acerbic criticism in recent years. These criticisms state that the brain disease view is deterministic, fails to account for heterogeneity in remission and recovery, places too much emphasis on a compulsive dimension of addiction, and that a specific neural signature of addiction has not been identified. We acknowledge that some of these criticisms have merit, but assert that the foundational premise that addiction has a neurobiological basis is fundamentally sound. We also emphasize that denying that addiction is a brain disease is a harmful standpoint since it contributes to reducing access to healthcare and treatment, the consequences of which are catastrophic.

Here, we therefore address these criticisms, and in doing so provide a contemporary update of the brain disease view of addiction. We provide arguments to support this view, discuss why apparently spontaneous remission does not negate it, and how seemingly compulsive behaviors can co-exist with the sensitivity to alternative reinforcement in addiction. Most importantly, we argue that the brain is the biological substrate from which both addiction and the capacity for behavior change arise, arguing for an intensified neuroscientific study of recovery. More broadly, we propose that these disagreements reveal the need for multidisciplinary research that integrates neuroscientific, behavioral, clinical, and sociocultural perspectives.

Proof of Concept for the Autobiographical Memory Flexibility (MemFlex) Intervention for Posttraumatic Stress Disorder

It would be particularly interesting if training autobiographical memory processes more broadly could positively affect the trauma memory or associated posttraumatic appraisals without the individual ever discussing the trauma or its meaning or deliberately retrieving the trauma memory itself. That is, we were interested in whether improving the ability to retrieve concrete, specific details of all memories would flow on to increases in the (typically poor) visual and sensory quality and temporal features of a trauma memory. Because poor quality of a trauma memory is associated with poorer prognosis (Ehlers & Clark, 2000), intervention-driven improvement in trauma memory quality may represent one potential mechanism through which autobiographical memory-based training programs help to improve PTSD (Hitchcock et al., 2017; Moradi et al., 2014).

Likewise, training someone to flexibly move between specific events and generalized representations of the past may help to constrain overly generalized, negative beliefs (as suggested by the results of Hitchcock et al., 2017). Because the extrapolation of meaning attributed to the trauma (e.g., other people cannot be trusted, there is something wrong with me as a person) to the self and world more broadly is another strong predictor of prognosis, any effect of intervention on generalized posttraumatic appraisals could represent an alternate mechanism through which autobiographical memory-based training programs help to improve PTSD.

Morphological integration of the human brain across adolescence and adulthood

Brain structural covariance norms capture the coordination of neurodevelopmental programs between different brain regions. We develop and apply anatomical imbalance mapping (AIM), a method to measure and model individual deviations from these norms, to provide a lifespan map of morphological integration in the human cortex. In cross-sectional and longitudinal data, analysis of whole-brain average anatomical imbalance reveals a reproducible tightening of structural covariance by age 25 y, which loosens after the seventh decade of life. Anatomical imbalance change in development and in aging is greatest in the association cortex and least in the sensorimotor cortex. Finally, we show that interindividual variation in whole-brain average anatomical imbalance is positively correlated with a marker of human prenatal stress (birthweight disparity between monozygotic twins) and negatively correlated with general cognitive ability. This work provides methods and empirical insights to advance our understanding of coordinated anatomical organization of the human brain and its interindividual variation.

In Pursuit of Pleasure, Brain Learns to Hit the Repeat Button

The mice quickly learned which musical arrangement that, when played, caused a dopamine release and the feel-good sensation. Their brains then began to rewire themselves to play that song more often, thereby triggering the pleasure hit of dopamine.

“In essence, the mice learned to repeat the same pattern of brain activity that had been evoked previously by hearing those musical notes,” said Vivek Athalye, a doctoral candidate at UC Berkeley and the paper’s co-first author.

The researchers noted that these findings are a striking example of Thorndike’s Law — a long-held principle of psychology stating that actions that lead to positive reinforcement are repeated more frequently. However, these findings likely represent the first time that this principle has been directly observed in the brain.

“In some ways, these results are entirely expected,” said Dr. Costa. “It makes sense that the brain would mimic the feeling of reward it gets from an enjoyable experience by producing the corresponding pattern of neural activity. But it had never been tested.”

The placebo effect and psychedelic drugs: Tripping on nothing?

Participants, who were expecting to take part in a study of the effects of drugs on creativity, spent four hours together in a room that had been set up to resemble a psychedelic party, with paintings, coloured lights and a DJ. To make the context seem credible and hide the deception, the study also involved ten research assistants in white lab coats, psychiatrists, and a security guard.

The 33 participants had been told they were being given a drug which resembled the active ingredient in psychedelic mushrooms and that they would experience changes in consciousness over the 4-hour period. In reality, everyone consumed a placebo. Among the participants were several actors who had been trained to slowly act out the effects of the ostensible drug. The researchers thought that this would help convince the participants that everyone had consumed a psychedelic drug and might lead them to experience placebo effects.

An amygdala-to-hypothalamus circuit for social reward

Social interactions and relationships are often rewarding, but the neural mechanisms through which social interaction drives positive experience remain poorly understood. In this study, we developed an automated operant conditioning system to measure social reward in mice and found that adult mice of both sexes display robust reinforcement of social interaction. Through cell-type-specific manipulations, we identified a crucial role for GABAergic neurons in the medial amygdala (MeA) in promoting the positive reinforcement of social interaction. Moreover, MeA GABAergic neurons mediate social reinforcement behavior through their projections to the medial preoptic area (MPOA) and promote dopamine release in the nucleus accumbens. Finally, activation of this MeA-to-MPOA circuit can robustly overcome avoidance behavior. Together, these findings establish the MeA as a key node for regulating social reward in both sexes, providing new insights into the regulation of social reward beyond the classic mesolimbic reward system.

The joy of being animal

It might well be in the rallying of our own bodily resources that our greatest opportunities lie. When we reconsider all that we gain by being animals, we’re confronted by some powerful resources for positive change. Just think of the gobsmacking beauty of bonding. If you have a dog beside you as you read this, bend down, look into her eyes, and stroke her. Via the hypothalamus inside your body, oxytocin will get to work, and dopamine – organic chemicals implicated in animal bonding – and, before you know it, you’ll be feeling good, even in the dark times of a pandemic.

And, as it happens, so will your dog, who will experience a similar physical response to the bond between you both. Oxytocin is produced in the hypothalamus of all mammals. In other words, our bodies might well be our best and most effective tool in the effort to strike a new balance between humans and the rest of the living world. If we can tip ourselves more into a bonding frame of mind, we might find it easier to recognise the beauty and intelligence that we’re hellbent on destroying. By accepting that we’re animals too, we create the opportunity to think about how we might play to the strengths of our evolutionary legacies in ways that we all stand to gain from. If we can build a better relationship with our own reality and, indeed, a better relationship with other animals, we’ll be on the road to recovery.

How Pixar Uses Hyper-Colors to Hack Your Brain

Glynn taps on the control panel keyboard and calls up a scene from Inside Out where Joy and Sadness walk into the Realm of the Subconscious. Glynn hits Play; Joy and Sadness enter a dark room and see a forest of giant broccoli, lit from the side so it seems outlined in a bright green. They move to a red staircase headed down into infinity and then meet another character, the clownish imaginary friend Bing Bong, imprisoned in a cage of candy-colored balloons. “These are all basically as saturated a color as one can achieve in digital cinema today,” Glynn says.

Then he cues it up again, in super-high-end digital cinema fireworks, using everything the screen can give us. “They go through the doors, and you see the little long shot of them in the distance, then all of a sudden we kind of have everything.” The shot widens, and the camera heads toward the broccoli forest, but now the broccoli is laser-pointer green, glowing against the blackness.

The red archway around the staircase is the most vivid red I have ever seen, and when Joy and Sadness start walking down the stairs, the edges of the screen disappear. The room, the world, is nothing but black except for the stairs. The balloons of Bing Bong’s prison look unearthly, like a Jeff Koons dog with eldritch powers. “I want to say 60 percent of this frame is outside the gamut of traditional digital cinema,” Glynn says. “We have a version of this film that has been creatively approved and built for exhibition on televisions that don’t exist yet.”