On Stress-Part One-Sapolsky

Blogging on Peer-Reviewed ResearchBy Daniel Lende 

In my research in Colombia, I dealt with teenagers across the spectrum—kids from good families with futures they could see, kids who had gone through more shit than most people will see in their lifetimes.  One kid, let’s call him Rafa, came from a small town outside of Bogotá, his family not in the best circumstances.  In my talking with Rafa, he dwelled on the horrible process of social exclusion that he went through—first the whispers and bad looks, then problems at school, the violence and rejection at home, and the final demand from a coalition of men, powerful and dangerous men, that he simply leave.  Sure, Rafa was no saint himself, but that’s not the point.  The dwelling on what other people did, that was the hard thing in his life when I met him.  He didn’t deal with that in the best way either, finding support in hate-filled ideologies and drug-using friends.  I don’t think many adults had ever just taken the time to talk with him, to get to know him.  And he still got kicked out of the school, a school that took in kids that had had problems elsewhere, during that year I knew him.  I remember that administrative meeting well.  No teacher spoke up for Rafa, and I didn’t count as the anthropologist.  So Rafa ran out of chances once again.  Except that is the wrong expression—he ran into chances that bopped him around like the ball on a roulette wheel, only to end up on zero.  It was people that did that. 

So that’s the ethnographic moment. 

Let’s turn to some other research. Robert Sapolsky’s work is widely known.  His best-selling book, Why Zebras Don’t Get Ulcers, is now in its third edition, and his Perspectives piece in Science has been cited 485 times according to Google Scholar.  He is acclaimed in biological anthropology circles because of his concern with mechanism, the elegance of his naturalistic studies with baboons in Kenya, and his consideration of the heavy stress-related costs of inequality.  The back cover of the Zebras book summarizes the core argument of the book, “When we worry or experience stress, our body turns on the same physiological responses that an animal does, but we usually do not turn off the stress-response in the same way—through fighting, fleeing, or other quick actions.  Over time, this chronic activation of the stress-response can make us literally sick.” 

Michael Blakey is better known for his critical archaeology work and his leadership with the New York African Burial Ground.  The work I will discuss, Blakey’s chapter “Beyond European Enlightenment” in the edited volume Building a New Biocultural Synthesis, has been cited 5 times according to Google Scholar.  His earlier chapter “Psychophysiological Stress as an Indicator of Disorder in Industrial Society” in the book Diagnosing America: Anthropology and Public Engagement has been cited all of once.  But it is Blakey’s work that has turned my mind around in the past few days in ways that Sapolsky never quite has.  These two posts will explore why the blurb on Sapolsky’s book is wrong and why that is important to what neuroanthropology can do. 

Today I will start with Sapolsky’s recent Science review “The Influence of Social Hierarchy on Primate Health.”  The article begins with the familiar “socioeconomic gradient,” where the “stepwise descent in socioeconomic status (SES) predicts increased risks of cardiovascular, respiratory, rheumatoid, and psychiatric diseases; low birth weight; infant mortality; and mortality from all causes.”  Sapolsky then provides a traditional review of the stress response—there are physical and psychosocial stressors, and both activate an “array of endocrine and neural adaptations.”  These adaptations are generally mobilized in response to challenges to homeostasis.  In response to “an acute physical challenge,” the stress response works through mobilizing energy, increasing cardiovascular tone, and inhibiting unessential anabolism; in other words, the classic “fight-or-flight” framing of stress.  Chronic activation, particular by chronic psychosocial stressors, can increase or worsen health problems ranging from “hypertension, atherosclerosis, insulin-resistant diabetes, immune suppression, reproductive impairments, and affective disorders.” 

Continue reading “On Stress-Part One-Sapolsky”

Introductions: Daniel Lende

Growing up I remember large poster boards covered by brain maps from localization studies in mammals.  The maps were odd, parts of the animal protruding, others minimally present, as if the raccoon or the opossum had stood in front of one of those twisting carnival mirrors.  Or been drawn by a caricature artist, emphasizing the parts of the animal that played a central role in their lives, their nose and whiskers, their paws, the parts of their bodies they used to interact with the world.  Those maps came from my father’s research; he was both a neurosurgeon and neuroanatomy researcher.  They showed the brain not as hard-wired circuits but as interactions.  They were also strikingly artistic, stark black and white prints mixed with surreal transformations.

In college I studied biological anthropology, interested in human evolution and animal behavior.  In the late eighties we had not hit the decade of the brain in the United States; I was more interested in evolutionary theory, psychological mechanisms and decision making.  The great expansion of the human brain during our evolutionary history, the importance of both tool making and sociality, the comparative approach of placing humans and other animals in the same framework to understand similarities and differences—these are lessons from that time that stay with me.

I lived in Bogotá, Colombia for several years after I graduated college.  I worked as a drug counselor and researcher, and earned extra money as a freelance journalist with articles mostly on business and tourism.  Those years impressed on me the power of culture, embodied in the new language I learned and the class differences that marked the geography of cities and homes alike, in what symbols people argued over and why the long Saturday lunch was such a cherished custom. But I didn’t forget my biology either, and I realized that for the problem that interested me—addiction—I needed to bring culture and biology together.  One of the main clues was in the descriptions boys provided to me about why they used drugs, the compulsion, craving (or “ansiedad” there) and desire they felt.  Addiction was “wanting more and more.”  These descriptions flew in the face of the then-current disease model of addiction, which was based on tolerance and withdrawal.  Withdrawal was tough, but it was the intense wanting, both while using and later, that seemed so destructive.  Thankfully these descriptions matched up with an emerging view of the brain and addiction based on the work of Terry Robinson and Kent Berridge at the University of Michigan, particularly a 1993 article on drug craving.

In my doctoral research, among many other things, I worked to link emerging conceptions of mesolimbic dopamine function with ethnographic descriptions of wanting and craving.  I worked with adolescents in Bogotá who ranged from non-drug users to people addicted to multiple substances.  The ethnography and the brain science matched up in three areas: intense desire for drugs, an urge to go towards drugs, and shifts in awareness towards drugs in the environment or how drugs could change one’s present feelings.  This view is not based on the essentialized “function” often proscribed onto certain parts of the brain (particularly as brain imaging elides into “seeing is believing”).  This reductionist view does not match up with the neuroanatomy or the experimental data.  Indeed, the overall mesolimbic dopamine system goes from some of our most ancient evolved brain systems to our most recent, with multiple projections that can have varied impact on on-going behavior and brain functioning.  And vice versa, as our bodies and environments can have varied impacts on brain functioning and behavior as well!

To summarize for now (I’ll hopefully expand later), the brain, grounded theory that works from people’s experiences and behavior, and the thick description of symbol systems can all hang together.  And you can even show that these things hang together with quantitative work, which I used by incorporating a new scale that formed part of my epidemiological work in Colombia.  This work is presented in my 2005 article in Ethos.  I remain deeply interested in this sort of integrative work, particularly how it plays out in multiple human domains, including addiction, anorexia, and sexual desire.I also haven’t forgotten my roots in biological anthropology.  Another part of my graduate work was to bring together evolutionary and cognitive neuroscience views of addiction.  My graduate mentor Neal Smith and I created a synthesis of evolutionary theory and neuroscience which describes a biopsychosocial approach to addiction.  I’ve just published a chapter that updates theses ideas, and provides clearer links to cultural anthropology, in the volume Neal edited on Evolutionary Medicine and Health.

At present I see an urgent need for theoretical mediators and ethnographic methods that help us work between what we know about our brains and what we know about our behavior and culture(s).  One rich area of work in this area centers on embodiment, and I hope that we will have a discussion on that topic as part of neuroanthropology.  Applied science or practical or engaged work also offers us another lens, whether it is figuring out how to make someone a better athlete or competitor or in trying to understand how to help someone who has a behavioral health problem.  So the applied side of neuroanthropology is another way we can draw on our ethnographic expertise, while also reflecting on and making a difference through what we do every day—live our lives through an encultured brain.

 If you want to reach me, please email me at dlende@nd.edu