A Few Too Many? Joan Acocella gives us the low-down on hang-overs, offering us hope (what little there is), science, anthropology, and even some morality! It’s a great article in The New Yorker, a neuroanth mash best enjoyed with a beer or a whiskey.
She covers the theories of why we have hang-overs in the first place, going through withdrawal, dehydration, inflammation (particularly due to cytokines), and congeners (impurities from the fermentation process). To these particularly bodily reactions, Acocella adds the role of genetics. Some people have a greater toxic response, often due to less alcohol dehydrogenase, an enzyme which breaks down alcohol. Others feel less of a withdrawal effect, building up tolerance more quickly.
Beyond the genetics, she also highlights an interesting theory to help explain hangovers. Wayne Jones has proposed that the liver process alcohol in two stages, first the ethanol (the alcohol) and then the methanol (a secondary ingredient in many wines and liquors). Methanol breaks down into formic acid, which is quite toxic. The main recipe to deal with this? Delay the move to methanol (drink some more) or distract yourself, say with spicy foods, to “divert the body’s attention away from coping with alcohol.” Or try comfort foods, again, to deal with the stress, inflammation, and toxins.
Neuroanthropology 